flecainide use increases digoxin concentration by about 20%
amiodarone causes a significant increase in plasma concentrations of flecainide
propranolol co-administration leads to a significant increase in plasma concentrations of both drugs
the use of negatively inotropic drugs with flecainide (e.g. verapamil, propranolol, disopyramide) increases the risk of heart failure (1)
cimetidine and fluoxetine may also increase flecainide concentrations
drugs which can prolong the QT interval (e.g. terfenadine, astemizole, quinine) when used with flecainide further increase the risk of serious ventricular arrhythmias
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