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Leser-Trelat Sign

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The Leser-Trelat Sign describes the rapid and widespread eruption of multiple seborrhoeic keratoses. It may be associated with acanthosis nigricans. Both skin lesions suggest the presence of visceral malignancy but the relationship is not proven (1).

The most frequent stated associations are with:

  • adenocarcinoma:
    • stomach
    • colon
    • breast

  • other possible associations include:
    • lymphoma
    • leukaemia
    • melanoma

Reference:

  • Primary Care Dermatology Society UK. Seborrhoeic keratosis (Accessed 30/7/14)

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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