HLA matching is an important determinant of graft survival:
Cadaveric grafts have an average half-life of 8 years. This compares to a half-life of 20 years for HLA-identical graft from a living related donor.
Many deaths are from cardiovascular pathology which often is unrelated to transplantation or to immunosuppression.
Transplant related death is most commonly due to infection or malignancy.
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