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Cautions and contra-indications

Authoring team

Cautions:

  • Haematological toxicity
    • blood tests should be carried out at least every 2 weeks for the first 3 months of treatment, then every 1-3 months
  • Renal and hepatic impairment
    • patients at risk of liver disease (including obese women, patients with hepatomegaly or hepatitis) require close monitoring
  • vitamin B12 efficiency
    • increased risk of neutropaenia
  • pregnancy and breast-feeding
  • elderly

Contra-indications:

  • Abnormally low neutrophil counts or haemoglobin values

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The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

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