spironolactone is an aldosterone antagonist used in the treatment of hypertension and has also been used in the treatment of FPHL
spironolactone also possesses antiandrogenic properties, acting as an androgen receptor antagonist and reducing the levels of cytochrome P450-dependent enzymes 17beta-hydroxylase and desmolase, which are both required for androgen synthesis
spironolactone has been shown to be safe and effective in the treatment of female pattern hair loss (FPHL) in adults
Reference:
1. Sinclair R, Wewerinke M, Jolley D. Treatment of female pattern hair loss with oral antiandrogens. Br. J. Dermatol. 2005; 152: 466-73.
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