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Laboratory events in monitoring sulphasalzine

Authoring team

Event: Value Action

Leucopaenia <3.5*10^9/l Stop & seek advice

Neutropaenia <2.5*10^9/l Stop & seek advice

Thrombocytopaenia <150*10^9/l Stop & seek advice

Macrocytosis >100 Check B12 and folate

Sequential falls >10% on Stop & seek advice in WCC or PMNs 3 occasions

Sequential falls >10% on Stop unless falls are from in platelets 3 occasions a high level, which is a response to treatment

Elevation of LFTs >3*normal Stop & repeat LFTs (AST, ALT, not ALP) Mild transaminitis is common


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