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Differential diagnosis

Authoring team

This includes:

  • other causes of leukoerythroblastosis:
    • severe infection or inflammation - but teardrop poikilocytosis and giant abnormal platelets absent

  • other causes of marrow fibrosis:
    • metastatic carcinoma
    • Hodgkin's disease
    • hairy cell leukaemia - all distinguished on basis of tissue morphology

  • other causes of massive splenomegaly:
    • chronic malaria
    • kala-azar
    • Gaucher's disease (rare)

  • other myeloproliferative disease:
    • Philadelphia chromosome and low leucocyte alkaline phosphatase in CML
    • raised haematocrit in polycythaemia vera
    • markedly raised platelets with normal red cell morphology in essential thromobocytosis

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