late complications can occur including pulmonary hypertension, hypersplenism, gall bladder disease, and chronic ankle ulceration. (1)
Moderate to severe Disease
severe anaemia, reduced exercise tolerance, mild to moderate bone changes, hypersplenism, poor growth during childhood, and a delay in pubertal development. (1)
they are likely to develop gall stones and have extramedullary haematopoietic masses. (1)
bone marrow expansion may cause malformation of facial bones, difficulty hearing or chewing and increased sinus infections (1). Pain and pathological fractures of long bones can also occur. (1)
liver iron deposition may occur due to increased iron absorption in the gut but easier to achieve negative iron balances than in thalassaemia major. (1)
pulmonary hypertension is an important complication and regular echo studies are needed to detect early. (1)
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