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Triazole antifungals

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Triazole antifungals include fluconazole, itraconazole, posaconazole, voriconazole.

While typically well-tolerated, triazoles can cause nausea, vomiting, diarrhoea, and abdominal pain. Hepatotoxicity (elevated liver function tests, hepatitis, cholestasis, and or fulminant liver failure) is also associated with all azoles.

All azoles should be avoided in patients with hypersensitivities to azole drugs or dosage form components, and used with caution in patients with renal impairment/failure and or hepatic impairment/failure.

References

  1. McKeny T et al. Antifungal Antibiotics. Treasure Island (FL): StatPearls Publishing. 2025 Jan.
  2. British National Formulary (BNF); NICE Evidence Services (UK access only)

 


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