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Investigation

Authoring team

Diagnosis is made on the basis of: (1,2)

  • high fasting plasma gastrin
  • high gastric acid secretion:
    • usually in excess of 100 mmol/h
  • diminished response to pentagastrin

localisation of tumour:

  • demonstrable pancreatic or gastrointestinal tumour - by CT or venous sampling for gastrin
  • more than 90% of gastrinomas have somatostatin receptors, and somatostatin receptor scintigraphy has been reported to be an especially sensitive method to image gastrinomas
  • also, with a skilled operator, endoscopic ultrasonography (also combined with biopsy) is also a very sensitive method to detect pancreatico-duodenal tumours

References:

  1. Zimmer V, Glanemann M, Lammert F; Zollinger-Ellison syndrome. CMAJ. 2019 Dec 9;191(49)
  2. Epelboym I, Mazeh H; Zollinger-Ellison syndrome: classical considerations and current controversies. Oncologist. 2014;19(1):44-50.

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