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Prasugrel and breastfeeding

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Prasugrel and Breastfeeding

  • use with caution
    • is no information on the amount of prasugrel which passes into breast milk although levels are likely to be low. It can be used with caution during breastfeeding but monitoring is required
  • monitoring
    • monitor the infant for skin reactions, and for signs of bruising or bleeding which could be prolonged

Notes:

  • is no published evidence of use of prasugrel during breastfeeding
  • LactMed states (2)
    • until more data become available, prasugrel should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant
  • prasugrel's high protein binding is likely to limit the amount excreted into milk. However, prasugrel irreversibly binds to platelets so any that is absorbed could have a prolonged effect
  • no side effects have been reported in breastfed infants

Reference:

  • NHS Specialist Pharmacy Service (July 2023). Using antiplatelet medicines during breastfeeding
  • Drugs and Lactation Database (LactMed [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006-. Prasugrel. [Updated 2019 Jun 3]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK543166/

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