Urobilinogen is a bile pigment that is produced by the degradation of conjugated bilirubin in the biliary tree and small intestine. It is water soluble and colourless.
Urobilinogen has several fates:
Hence, urobilinogen is present in the urine of normal subjects. If there is an increase in urobilinogen in the urine then this indicates hepato-cellular dysfunction or an increased bilirubin formation, e.g. due to haemolysis. In intrahepatic obstruction there is no urobilinogen in the urine.
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