This site is intended for healthcare professionals

Sign in
Go to /sign-in page

You can view 5 more pages before signing in

Effects

Authoring team

PAF can produce a range of inflammatory phenomena, even at low concentration; some responses are concentration-dependent:

  • at low concentration, vasodilatation; at higher concentration, vasoconstriction
  • increased venular permeability
  • platelet aggregation and degranulation
  • neutrophil aggregation, endothelial adhesion and chemotaxis
  • smooth muscle contraction in lung and gastrointestinal tract
  • synthesis of other mediators e.g. prostanoids, and synergism with their effects

Hence, administration of PAF to animal models can produce effects varying in severity between localised inflammation and anaphylactic shock.

Create an account to add page annotations

Create a free account

Add information to this page that would be handy to have on hand during a consultation, such as a web address or phone number. This information will always be displayed when you visit this page

The content herein is provided for informational purposes and does not replace the need to apply professional clinical judgement when diagnosing or treating any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions.

Connect

Copyright 2024 Oxbridge Solutions Limited, a subsidiary of OmniaMed Communications Limited. All rights reserved. Any distribution or duplication of the information contained herein is strictly prohibited. Oxbridge Solutions receives funding from advertising but maintains editorial independence.