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Pathology

Authoring team

The tumour is well demarcated from the surrounding breast tissue by a condensed connective tissue capsule.

The tumour develops from a whole lobule and not from a single cell. Microscopically, the tumour comprises proliferation of the connective tissue stroma and atypical multiplication of ducts and acini.

Two histological patterns are noted:

  • pericanicular - connective tissue stroma surrounds small islands of glandular tissue, in a whorled pattern

  • intracanicular - connective tissue stroma predominates and compresses the gland spaces; the epithelial elements appear as narrow strands or cords of epithelium lying within the fibrous tissue

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