Glucogenesis is undesirable when a cell has low nucleotide phosphate energy reserves. Hence, to limit gluconeogenesis, an elevated concentration of adenosine mono- or diphosphate relative to adenosine triphosphate acts to inhibit:
Both of these enzymes are non-equilibrium and flux-generating. When their activity is reduced, glycolysis is the prefered route of substrate passage; this is reinforced by adenosine monophosphate activating 6-phosphofructokinase.
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